AVEN anticorps (C-Term)

N° du produit ABIN6990365

Détail du produit anti-AVEN anticorps

Antigène: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AVEN est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Aven Antibody is affinity chromatography purified via peptide column.

Immunogène: Aven antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Aven. The immunogen is located within the last 50 amino acids of Aven.

Isotype: IgG

Information d'application

Indications d'application: Aven antibody can be used for detection of Aven by Western blot at 1 μ,g/mL. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Aven Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Aven antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur AVEN

Antigène: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Autre désignation: Aven (AVEN Produits)

Synonymes: anticorps AVEN, anticorps pdcd12, anticorps aven, anticorps wu:fc08c09, anticorps si:ch211-150c22.4, anticorps PDCD12, anticorps 1700013A01Rik, anticorps 1700056A21Rik, anticorps mAven-L, anticorps mAven-S, anticorps apoptosis and caspase activation inhibitor, anticorps apoptosis, caspase activation inhibitor L homeolog, anticorps apoptosis, caspase activation inhibitor, anticorps Aven, anticorps AVEN, anticorps aven.L, anticorps aven

Sujet: Aven Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.

ID gène: 57099

NCBI Accession: NP_065104

UniProt: Q9NQS1