MTBP anticorps (AA 110-160)

N° du produit ABIN6990370

Cet anticorps Lapin Polyclonal détecte spécifiquement MTBP dans WB, ELISA, ICC et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour MTBP anticorps (AA 110-160) (ABIN6990370)

Antigène: MTBP (MDM2 Binding Protein (MTBP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MTBP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-MTBP anticorps

Épitope: AA 110-160

Purification: MTBP Antibody is affinity chromatography purified via peptide column.

Immunogène: MTBP antibody was raised against a 18 amino acid peptide near the center of human MTBP. The immunogen is located within amino acids 110 - 160 of MTBP.

Isotype: IgG

Information d'application

Indications d'application: MTBP antibody can be used for detection of MTBP by Western blot at 1 to 2 μ,g/mL. A 104 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: MTBP Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: MTBP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur MTBP

Antigène: MTBP (MDM2 Binding Protein (MTBP))

Autre désignation: MTBP

Sujet: MTBP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2 and MTBP, were recently discovered. The transcriptional activity of p53 is modulated by posttranslational regulations of the p53 protein including stabilization and acetylation. P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein. MDM2 inhibits both p53 mediated G1 arrest and apoptosis. A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53. MTBP is expressed in a variety of normal tissues.

Poids moléculaire: Predicted: 104 kDa

Observed: 104 kDa

ID gène: 27085

NCBI Accession: NP_071328

UniProt: Q96DY7