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PHAP I anticorps (C-Term)

Reactivité: Humain, Souris, Rat WB, ELISA, IF, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6990427
  • Antigène Tous les produits PHAP I
    PHAP I
    Épitope
    C-Term
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 1
    Lapin
    Clonalité
    • 1
    Polyclonal
    Conjugué
    • 1
    Cet anticorp PHAP I est non-conjugé
    Application
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificité
    This polyclonal antibody has no cross-reaction to PHAP I2a and PHAP III.
    Purification
    PHAP I Antibody is affinity chromatography purified via peptide column.
    Immunogène
    Anti-PHAP I antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human PHAP I . The immunogen is located within the last 50 amino acids of PHAP I.
    Isotype
    IgG
  • Indications d'application
    WB: 1 μ,g/mL, IHC: 2 μ,g/mL, IF: 20 μ,g/mL.

    Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in mouse samples, Immunofluorescence in mouse samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PHAP I Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    PHAP I antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    PHAP I
    Abstract
    PHAP I Produits
    Sujet
    PHAP I Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
    Poids moléculaire
    Predicted: 29kD

    Observed: 29 kD kDa
    ID gène
    8125
    UniProt
    P39687
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