BIRC6 anticorps (C-Term)

N° du produit ABIN6990463

Cet anticorps Lapin Polyclonal détecte spécifiquement BIRC6 dans ELISA et IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour BIRC6 anticorps (C-Term) (ABIN6990463)

Antigène: BIRC6 (Baculoviral IAP Repeat-Containing 6 (BIRC6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BIRC6 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-BIRC6 anticorps

Épitope: AA 4760-4810, C-Term

Specificité: BRUCE antibody is human specific. Multiple isoforms of BRUCE are known to exist.

Purification: BRUCE Antibody is affinity chromatography purified via peptide column.

Immunogène: BRUCE antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human BRUCE. The immunogen is located within amino acids 4760 - 4810 of BRUCE.

Isotype: IgG

Information d'application

Indications d'application: BRUCE antibody can be used for detection of BRUCE by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: BRUCE Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: BRUCE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur BIRC6

Antigène: BIRC6 (Baculoviral IAP Repeat-Containing 6 (BIRC6))

Autre désignation: BRUCE

Sujet: BRUCE Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.

Poids moléculaire: 534 kDa

ID gène: 57448

NCBI Accession: NP_057336

UniProt: Q9NR09