IL-27 anticorps (AA 80-130)

N° du produit ABIN6990634

Cet anticorps Lapin Polyclonal détecte spécifiquement IL-27 dans WB et ELISA. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour IL-27 anticorps (AA 80-130) (ABIN6990634)

Antigène: IL-27 (IL27) (Interleukin 27 (IL27))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL-27 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-IL-27 anticorps

Épitope: AA 80-130

Purification: IL-27 Antibody is affinity chromatography purified via peptide column.

Immunogène: Anti-IL-27 antibody was raised against a peptide corresponding to 14 amino acids near the center of human IL-27. The immunogen is located within amino acids 80 - 130 of IL-27.

Isotype: IgG

Information d'application

Indications d'application: WB: 2-4 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: IL-27 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: IL-27 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur IL-27

Antigène: IL-27 (IL27) (Interleukin 27 (IL27))

Autre désignation: IL-27

Sujet: IL-27 Antibody: Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.

Poids moléculaire: Predicted: 28 kDa

Observed: 28 kDa

ID gène: 246778

NCBI Accession: NP_663634

UniProt: Q8NEV9