Cyclin O anticorps (N-Term)

N° du produit ABIN6990651

Cet anticorps anti-Cyclin O Polyclonal Lapin (ABIN6990651) détecte spécifiquement Cyclin O dans ELISA et WB. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Cyclin O anticorps (N-Term) (ABIN6990651)

Antigène: Cyclin O (CCNO)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin O est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-Cyclin O anticorps

Épitope: N-Term

Specificité: At least two isoforms of Cyclin O are known to exist, this antibody will recognize both isoforms.

Purification: Cyclin O Antibody is affinity chromatography purified via peptide column.

Immunogène: Cyclin O antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human Cyclin O. The immunogen is located within the first 50 amino acids of Cyclin O.

Isotype: IgG

Information d'application

Indications d'application: Cyclin O antibody can be used for the detection of Cyclin O by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Cyclin O Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Cyclin O antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur Cyclin O

Antigène: Cyclin O (CCNO)

Autre désignation: Cyclin O

Sujet: Cyclin O Antibody: Cyclin O, also known as CCNO, has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to instrinsic apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Supression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. Note: this gene, which had a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase. A later publication identified this gene's product as a cyclin protein family member.

Poids moléculaire: 39 kDa

ID gène: 10309

NCBI Accession: NP_066970

UniProt: P22674