ORAI3 anticorps (N-Term)

N° du produit ABIN6990743

Détail du produit anti-ORAI3 anticorps

Antigène: ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))

Épitope: N-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ORAI3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2.

Purification: ORAI3 Antibody is affinity chromatography purified via peptide column.

Immunogène: ORAI3 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human ORAI3. The immunogen is located within the first 50 amino acids of ORAI3.

Isotype: IgG

Information d'application

Indications d'application: ORAI3 antibody can be used for detection of ORAI3 by Western blot at 1 - 4 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL and Immunohistochemistry starting at 2 μ,g/mL

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ORAI3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ORAI3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur ORAI3

Antigène: ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))

Autre désignation: ORAI3 (ORAI3 Produits)

Synonymes: anticorps ORAI3, anticorps TMEM142C, anticorps 9930124N15, anticorps BC061259, anticorps Tmem142c, anticorps RGD1306538, anticorps ORAI calcium release-activated calcium modulator 3, anticorps ORAI3, anticorps Orai3

Sujet: ORAI3 Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter.

ID gène: 93129

UniProt: Q9BRQ5