TACR3 anticorps (AA 370-420)

N° du produit ABIN6990763

Cet anticorps Lapin Polyclonal détecte spécifiquement TACR3 dans WB, ELISA, IF et IHC (p). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour TACR3 anticorps (AA 370-420) (ABIN6990763)

Antigène: TACR3 (Tachykinin Receptor 3 (TACR3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TACR3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-TACR3 anticorps

Épitope: AA 370-420

Specificité: NK3R antibody does not recognize NK1R or NK2R.

Purification: NK3R Antibody is affinity chromatography purified via peptide column.

Immunogène: NK3R antibody was raised against a 18 amino acid synthetic peptide from near the center of human NK3R. The immunogen is located within amino acids 370 - 420 of NK3R.

Isotype: IgG

Information d'application

Indications d'application: NK3R antibody can be used for detection of NK3R by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: NK3R Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: NK3R antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TACR3

Antigène: TACR3 (Tachykinin Receptor 3 (TACR3))

Autre désignation: NK3R

Sujet: NK3R Antibody: The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.

Poids moléculaire: Predicted: 51 kDa

Observed: 51 kDa

ID gène: 6870

UniProt: P29371

Pathways: Feeding Behaviour