STEAP1 anticorps (C-Term)

N° du produit ABIN6990784

Cet anticorps Lapin Polyclonal détecte spécifiquement STEAP1 dans WB, ELISA et IHC (p). Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour STEAP1 anticorps (C-Term) (ABIN6990784)

Antigène: STEAP1 (Six Transmembrane Epithelial Antigen of The Prostate 1 (STEAP1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STEAP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-STEAP1 anticorps

Épitope: C-Term

Specificité: This STEAP1 antibody does not cross-react with other STEAP proteins.

Purification: STEAP1 Antibody is affinity chromatography purified via peptide column.

Immunogène: STEAP1 antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human STEAP1. The immunogen is located within the last 50 amino acids of STEAP1.

Isotype: IgG

Information d'application

Indications d'application: STEAP1 antibody can be used for detection of STEAP1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: STEAP1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: STEAP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur STEAP1

Antigène: STEAP1 (Six Transmembrane Epithelial Antigen of The Prostate 1 (STEAP1))

Autre désignation: STEAP1

Sujet: STEAP1 Antibody: The six-transmembrane epithelial antigen of prostate 1 (STEAP1) was the first member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. The normal function of STEAP is still uncertain, unlike other members of the STEAP family, STEAP1 does not promote iron or copper reduction or uptake and lacks the FNO-like reductase domain critical for activity. However, its expression is highly increased in multiple cancer cell lines, including prostate, bladder, colon, and ovarian cancers. Supporting this is evidence that STEAP1 peptides can be used to stimulate CD8+ T cells from healthy donors, enabling them to recognize STEAP1-positive human tumor cells, suggesting that STEAP1 may a potential target for cancer immunotherapy. At least three isoforms of STEAP1 are known to exist.

ID gène: 26872

UniProt: Q9UHE8

Pathways: Transition Metal Ion Homeostasis