CD248 anticorps (N-Term)

N° du produit ABIN6990809

L’anticorps Lapin Polyclonal anti-CD248 a été validé pour WB, ELISA, IHC (p) et IF. Il convient pour détecter CD248 dans des échantillons de Humain.

Aperçu rapide pour CD248 anticorps (N-Term) (ABIN6990809)

Antigène: CD248 (CD248 Molecule, Endosialin (CD248))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD248 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-CD248 anticorps

Épitope: AA 40-90, N-Term

Specificité: At least two isoforms of TEM1 are known to exist, this antibody recognizes only the larger isoform.

Purification: TEM1 Antibody is affinity chromatography purified via peptide column.

Immunogène: Anti-TEM-1 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human TEM-1. The immunogen is located within amino acids 40-90 of TEM-1

Isotype: IgG

Information d'application

Indications d'application: WB: 0.5-2 μ,g/mL, IHC-P: 2.5 μ,g/mL, IF: 20 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TEM1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: TEM1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur CD248

Antigène: CD248 (CD248 Molecule, Endosialin (CD248))

Autre désignation: TEM1

Sujet: TEM1 Antibody: Tumor endothelial marker (TEM) 1 was originally identified as a human embryonic fibroblast-specific antigen and was later determined to be endosialin, a single-pass transmembrane glycoprotein that has multiple extracellular domains, including three EGF-like domains, a sushi-like domain, and a C lectin-like domain. TEM proteins are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. While TEM1 is not required for angiogenesis during fetal development, postnatal growth or wound healing, it plays a role in tumor growth, invasion, and metastasis. Fibronectin and collagen types I and IV act as specific ligands of TEM1, leading to suggestions that these molecules may cause changes in the extracellular matrix, cell adhesion and migration during tumor invasion.

Poids moléculaire: Predicted: 81kD

Observed: 90 kD (post-modifications: 27 O-linked glycosylations) kDa

ID gène: 57124

NCBI Accession: NP_065137

UniProt: Q9HCU0