TOCA-1 Antibody is affinity chromatography purified via peptide column.
Immunogène
TOCA-1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human TOCA-1. The immunogen is located within the last 50 amino acids of TOCA-1.
FNBP1L
Reactivité: Humain
IF (cc), IF (p)
Hôte: Lapin
Polyclonal
FITC
Indications d'application
TOCA-1 antibody can be used for detection of TOCA-1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Restrictions
For Research Use only
Format
Liquid
Concentration
1 mg/mL
Buffer
TOCA-1 Antibody is supplied in PBS containing 0.02 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C,4 °C
Stockage commentaire
TOCA-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
anticorps C1orf39, anticorps TOCA1, anticorps 2610318I01Rik, anticorps AW548221, anticorps RGD1305386, anticorps Toca-1, anticorps zgc:100923, anticorps toca1, anticorps toca-1, anticorps MGC132162, anticorps fnbp1l, anticorps formin binding protein 1 like, anticorps formin binding protein 1-like, anticorps formin binding protein 1 like L homeolog, anticorps formin binding protein 1 like S homeolog, anticorps FNBP1L, anticorps Fnbp1l, anticorps fnbp1l, anticorps fnbp1l.L, anticorps fnbp1l.S
Sujet
TOCA-1 Antibody: Actin reorganization is important for the regulation of neuronal morphology. A protein involved in this process, the transducer of cdc42-dependent actin assembly 1 (TOCA-1) protein, a member of the evolutionarily conserved pombe CDC15 homology (PCH) protein family, is an essential component of the Cdc42 pathway. TOCA-1 binds both N-WASP and Cdc42 and is essential for Cdc42- and PIP2-induced actin polymerization, suggesting that TOCA-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Decreased expression of TOCA-1 significantly enhances neurite elongation in PC-12 cells, its overexpression in the same cells suppresses neurite elongation. It has been suggested that TOCA-1 negatively regulates axon branching by regulating membrane trafficking by regulating membrane trafficking through the F-BAR/EFC domain. Multiple isoforms of TOCA-1 are known to exist.