RIMS2 anticorps (AA 840-890)

N° du produit ABIN6990846

Cet anticorps anti-RIMS2 est un anticorps Lapin Polyclonal détectant RIMS2 dans ELISA et IHC (p). Adapté pour Humain.

Aperçu rapide pour RIMS2 anticorps (AA 840-890) (ABIN6990846)

Antigène: RIMS2 (Regulating Synaptic Membrane Exocytosis 2 (RIMS2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RIMS2 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-RIMS2 anticorps

Épitope: AA 840-890

Specificité: RIM2 antibody is human specific. Multiple isoforms of RIM2 are known to exist.

Purification: RIM2 Antibody is affinity chromatography purified via peptide column.

Immunogène: RIM2 antibody was raised against a 17 amino acid synthetic peptide near the center of human RIM2. The immunogen is located within amino acids 840 - 890 of RIM2.

Isotype: IgG

Information d'application

Indications d'application: RIM2 antibody can be used for detection of RIM2 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: RIM2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: RIM2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur RIMS2

Antigène: RIMS2 (Regulating Synaptic Membrane Exocytosis 2 (RIMS2))

Autre désignation: RIM2

Sujet: RIM2 Antibody: Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release, synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.

ID gène: 9699

NCBI Accession: NP_001093587

UniProt: Q9UQ26

Pathways: Hormone Transport, Synaptic Vesicle Exocytosis