FBXL20 anticorps (C-Term)

N° du produit ABIN6990847

Cet anticorps Lapin Polyclonal détecte spécifiquement FBXL20 dans ELISA, WB et IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour FBXL20 anticorps (C-Term) (ABIN6990847)

Antigène: FBXL20 (F-Box and Leucine-Rich Repeat Protein 20 (FBXL20))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXL20 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-FBXL20 anticorps

Épitope: C-Term

Purification: SCRAPPER Antibody is affinity chromatography purified via peptide column.

Immunogène: SCRAPPER antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of the human SCRAPPER. The immunogen is located within the last 50 amino acids of SCRAPPER.

Isotype: IgG

Information d'application

Indications d'application: SCRAPPER antibody can be used for detection of SCRAPPER by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: SCRAPPER Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: SCRAPPER antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur FBXL20

Antigène: FBXL20 (F-Box and Leucine-Rich Repeat Protein 20 (FBXL20))

Autre désignation: SCRAPPER

Sujet: SCRAPPER Antibody: Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.

ID gène: 84961

NCBI Accession: NP_116264

UniProt: Q96IG2