AMBRA1 anticorps (C-Term)

N° du produit ABIN6990888

Détail du produit anti-AMBRA1 anticorps

Antigène: AMBRA1 (Autophagy/beclin-1 Regulator 1 (AMBRA1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AMBRA1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Ambra1 Antibody is affinity chromatography purified via peptide column.

Immunogène: Ambra1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human Ambra1. The immunogen is located within the last 50 amino acids of Ambra1.

Isotype: IgG

Information d'application

Indications d'application: Ambra1 antibody can be used for the detection of Ambra1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Ambra1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Ambra1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur AMBRA1

Antigène: AMBRA1 (Autophagy/beclin-1 Regulator 1 (AMBRA1))

Autre désignation: Ambra1 (AMBRA1 Produits)

Synonymes: anticorps 2310079H06Rik, anticorps A130023A14, anticorps AA474864, anticorps AV021921, anticorps D030051N19Rik, anticorps mKIAA1736, anticorps Nyw1, anticorps DCAF3, anticorps WDR94, anticorps autophagy and beclin 1 regulator 1, anticorps autophagy/beclin-1 regulator 1a, anticorps autophagy/beclin 1 regulator 1, anticorps AMBRA1, anticorps ambra1a, anticorps Ambra1

Sujet: Ambra1 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Beclin-1, a principal regulator of autophagosome formation, is in turn regulated by Ambra1. Ambra1 associates with Beclin-1 through a region near its center as determined by yeast two-hybrid assay. Null mutations in this gene in mice resulted in embryonic lethality with severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic death. Furthermore, down-regulation of Ambra1 in cultured cells though RNA interference decreased the level of rapamycin- and nutrient starvation-induced autophagy. Multiple isoforms of Ambra1 are known to exist.

ID gène: 55626

UniProt: Q9C0C7

Pathways: Autophagy