Transportin 3 anticorps (N-Term)

N° du produit ABIN6990902

L’anticorps Lapin Polyclonal anti-Transportin 3 a été validé pour ELISA et WB. Il convient pour détecter Transportin 3 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Transportin 3 anticorps (N-Term) (ABIN6990902)

Antigène: Transportin 3 (TNPO3)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Transportin 3 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-Transportin 3 anticorps

Épitope: AA 140-190, N-Term

Purification: TNPO3 Antibody is affinity chromatography purified via peptide column.

Immunogène: TNPO3 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human TNPO3. The immunogen is located within amino acids 140 - 190 of TNPO3.

Isotype: IgG

Information d'application

Indications d'application: TNPO3 antibody can be used for detection of TNPO3 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TNPO3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: TNPO3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur Transportin 3

Antigène: Transportin 3 (TNPO3)

Autre désignation: TNPO3

Sujet: TNPO3 Antibody: TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.

Poids moléculaire: Predicted: 105 kDa

Observed: 99 kDa

ID gène: 23534

UniProt: Q9Y5L0

Pathways: Protein targeting to Nucleus