RIMS2 anticorps (AA 250-300)

N° du produit ABIN6990907

Cet anticorps Lapin Polyclonal détecte spécifiquement RIMS2 dans ELISA, WB, IHC (p) et IF. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour RIMS2 anticorps (AA 250-300) (ABIN6990907)

Antigène: RIMS2 (Regulating Synaptic Membrane Exocytosis 2 (RIMS2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RIMS2 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-RIMS2 anticorps

Épitope: AA 250-300

Specificité: Multiple isoforms of RIM2 are known to exist. This antibody is predicted to have no cross-reactivity to other Rim proteins.

Purification: Rim2 Antibody is affinity chromatography purified via peptide column.

Immunogène: Rim2 antibody was raised against a 17 amino acid synthetic peptide near the center of the human Rim2. The immunogen is located within amino acids 250 - 300 of Rim2.

Isotype: IgG

Information d'application

Indications d'application: Rim2 antibody can be used for detection of Rim2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rim2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Rim2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur RIMS2

Antigène: RIMS2 (Regulating Synaptic Membrane Exocytosis 2 (RIMS2))

Autre désignation: Rim2

Sujet: Rim2 Antibody: Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release, synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim 2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.

Poids moléculaire: Predicted: 39, 128, 148, 170 kDa

Observed: 128 kDa

ID gène: 9699

NCBI Accession: NP_001093587

UniProt: Q9UQ26

Pathways: Hormone Transport, Synaptic Vesicle Exocytosis