Syntaphilin anticorps (AA 350-400)

N° du produit ABIN6990920

L’anticorps Lapin Polyclonal anti-Syntaphilin a été validé pour WB, ELISA, IHC (p) et IF. Il convient pour détecter Syntaphilin dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Syntaphilin anticorps (AA 350-400) (ABIN6990920)

Antigène: Syntaphilin (SNPH)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Syntaphilin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-Syntaphilin anticorps

Épitope: AA 350-400

Purification: Syntaphilin Antibody is affinity chromatography purified via peptide column.

Immunogène: Syntaphilin antibody was raised against a 16 amino acid synthetic peptide from near the center of human Syntaphilin. The immunogen is located within amino acids 350 - 400 of Syntaphilin.

Isotype: IgG

Information d'application

Indications d'application: Syntaphilin antibody can be used for detection of Syntaphilin by Western blot at 1 - 2 μ,g/mL. Despite its predicted molecular weight, Syntaphilin usually migrates at higher molecular weight in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Syntaphilin Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Syntaphilin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur Syntaphilin

Antigène: Syntaphilin (SNPH)

Autre désignation: Syntaphilin

Sujet: Syntaphilin Antibody: Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function. Multiple isoforms are known to exist.

ID gène: 9751

UniProt: O15079

Pathways: Synaptic Vesicle Exocytosis