BST2 anticorps (N-Term)

N° du produit ABIN6990931

Détail du produit anti-BST2 anticorps

Antigène: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Épitope: AA 60-110, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BST2 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Bst2 Antibody is affinity chromatography purified via peptide column.

Immunogène: Bst2 antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of the mouse Bst2. The immunogen is located within amino acids 60 - 110 of Bst2.

Isotype: IgG

Information d'application

Indications d'application: Bst2 antibody can be used for detection of Bst2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Bst2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Bst2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur BST2

Antigène: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Autre désignation: Bst2 (BST2 Produits)

Synonymes: anticorps BST2, anticorps CD317, anticorps TETHERIN, anticorps 2310015I10Rik, anticorps Bst-2, anticorps C87040, anticorps DAMP-1, anticorps GREG, anticorps Damp1, anticorps bone marrow stromal cell antigen 2, anticorps bone marrow stromal antigen 2, anticorps BST2, anticorps LOC618737, anticorps Bst2

Sujet: Bst2 Antibody: Bst2 was first identified as a novel terminal B-cell-restricted antigen termed HM1.24 that is expressed on certain bone marrow cells as well as other tissues. The surface expression of Bst2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line, suggesting that this protein is involved in pre-B-cell growth. Later experiments also showed it to be upregulated in several myeloma cells. More recently, Bst2 was identified an inhibitor of retroviral release from human cells whose activity is antagonized by the HIV-1 accessory protein Vpu. While Bst2 caused retention of virions on cell surfaces or endocytosis into Bst2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release. This activity may represent a potential therapeutic strategy for the treatment of HIV/AIDS.

ID gène: 69550

UniProt: Q8R2Q8

Pathways: Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response