LASS5 anticorps (C-Term)

N° du produit ABIN6990940

Cet anticorps Lapin Polyclonal détecte spécifiquement LASS5 dans WB, ELISA et IF. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour LASS5 anticorps (C-Term) (ABIN6990940)

Antigène: LASS5 (LAG1 Homolog, Ceramide Synthase 5 (LASS5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LASS5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-LASS5 anticorps

Épitope: C-Term

Specificité: Multiple isoforms of LASS5 are known to exist. This antibody may cross-react with the highly homologous LASS6.

Purification: LASS5 Antibody is affinity chromatography purified via peptide column.

Immunogène: LASS5 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human LASS5. The immunogen is located within the last 50 amino acids of LASS5.

Isotype: IgG

Information d'application

Indications d'application: LASS5 antibody can be used for detection of LASS5 by Western blot at 1 μ,g/mL. Antibody can also be used for immunoflourescence starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: LASS5 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: LASS5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur LASS5

Antigène: LASS5 (LAG1 Homolog, Ceramide Synthase 5 (LASS5))

Autre désignation: LASS5

Sujet: LASS5 Antibody: The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis.

ID gène: 91012

NCBI Accession: NP_671723

UniProt: Q8N5B7