GP6 anticorps (AA 130-180)

N° du produit ABIN6990966

Détail du produit anti-GP6 anticorps

Antigène: GP6 (Glycoprotein VI (Platelet) (GP6))

Épitope: AA 130-180

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GP6 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: GPVI Antibody is affinity chromatography purified via peptide column.

Immunogène: GPVI antibody was raised against a 18 amino acid synthetic peptide near the center of the human GPVI. The immunogen is located within amino acids 130 - 180 of GPVI.

Isotype: IgG

Information d'application

Indications d'application: GPVI antibody can be used for detection of GPVI by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: GPVI Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: GPVI antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur GP6

Antigène: GP6 (Glycoprotein VI (Platelet) (GP6))

Autre désignation: GPVI (GP6 Produits)

Synonymes: anticorps BDPLT11, anticorps GPIV, anticorps GPVI, anticorps 9830166G18Rik, anticorps Gm469, anticorps Gpvi, anticorps GP6, anticorps glycoprotein VI platelet, anticorps glycoprotein 6 (platelet), anticorps glycoprotein VI, anticorps platelet glycoprotein VI, anticorps GP6, anticorps Gp6, anticorps LOC103346235

Sujet: GPVI Antibody: Glycoprotein VI (GP6) is a 58kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. It is uniquely expressed by cells of the megakaryocytic/platelet lineage, and is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcRgamma) and natural killer receptors. Glycoprotein VI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcRgamma, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. GPVI deficiency can result in bleeding disorders. Further study should reveal the extent of GPVI involvement in thrombotic disease and allow the development of alternative anti-thrombotic compounds.

Poids moléculaire: Predicted: 37, 68 kDa

Observed: 55 kDa 

ID gène: 51206

NCBI Accession: NP_057447

UniProt: Q9HCN6