PRTFDC1 anticorps (AA 90-140)

N° du produit ABIN6990967

Cet anticorps Lapin Polyclonal détecte spécifiquement PRTFDC1 dans WB et ELISA. Il présente une réactivité envers Humain et Rat.

Aperçu rapide pour PRTFDC1 anticorps (AA 90-140) (ABIN6990967)

Antigène: PRTFDC1 (phosphoribosyl Transferase Domain Containing 1 (PRTFDC1))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRTFDC1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-PRTFDC1 anticorps

Épitope: AA 90-140

Purification: PRTFDC1 Antibody is affinity chromatography purified via peptide column.

Immunogène: PRTFDC1 antibody was raised against a 14 amino acid synthetic peptide from near the center of human PRTFDC1. The immunogen is located within amino acids 90 - 140 of PRTFDC1.

Isotype: IgG

Information d'application

Indications d'application: PRTFDC1 antibody can be used for detection of PRTFDC1 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PRTFDC1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: PRTFDC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur PRTFDC1

Antigène: PRTFDC1 (phosphoribosyl Transferase Domain Containing 1 (PRTFDC1))

Autre désignation: PRTFDC1

Sujet: PRTFDC1 Antibody: Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.

ID gène: 56952

NCBI Accession: NP_064585

UniProt: Q9NRG1

Pathways: Ribonucleoside Biosynthetic Process