FERMT3 anticorps (C-Term)

N° du produit ABIN6990977

Détail du produit anti-FERMT3 anticorps

Antigène: FERMT3 (Fermitin Family Member 3 (FERMT3))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FERMT3 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: KINDLIN3 Antibody is affinity chromatography purified via peptide column.

Immunogène: KINDLIN3 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of the human KINDLIN3. The immunogen is located within the last 50 amino acids of KINDLIN3.

Isotype: IgG

Information d'application

Indications d'application: KINDLIN3 antibody can be used for detection of KINDLIN3 by Western blot at 1 and 2 μ,g/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: KINDLIN3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: KINDLIN3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur FERMT3

Antigène: FERMT3 (Fermitin Family Member 3 (FERMT3))

Autre désignation: KINDLIN3 (FERMT3 Produits)

Synonymes: anticorps C79673, anticorps Kindlin3, anticorps RGD1310168, anticorps MGC69069, anticorps MGC88900, anticorps KIND3, anticorps MIG-2, anticorps MIG2B, anticorps UNC112C, anticorps URP2, anticorps URP2SF, anticorps zgc:64101, anticorps fermitin family member 3, anticorps fermitin family member 3 L homeolog, anticorps fermitin family member 3b, anticorps Fermt3, anticorps fermt3.L, anticorps fermt3, anticorps FERMT3, anticorps fermt3b

Sujet: KINDLIN3 Antibody: The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.

Poids moléculaire: Predicted: 73 kDa

Observed: 73 kDa

ID gène: 83706

NCBI Accession: NP_848537

UniProt: Q86UX7