AKIRIN2 anticorps (AA 80-130)

N° du produit ABIN6990981

Cet anticorps anti-AKIRIN2 Polyclonal Lapin (ABIN6990981) détecte spécifiquement AKIRIN2 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour AKIRIN2 anticorps (AA 80-130) (ABIN6990981)

Antigène: AKIRIN2 (Akirin 2 (AKIRIN2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AKIRIN2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-AKIRIN2 anticorps

Épitope: AA 80-130

Purification: Akirin2 Antibody is affinity chromatography purified via peptide column.

Immunogène: Akirin2 antibody was raised against a 15 amino acid synthetic peptide near the center of the human Akirin2. The immunogen is located within amino acids 80 - 130 of Akirin2.

Isotype: IgG

Information d'application

Indications d'application: Akirin2 antibody can be used for detection of Akirin2 by Western blot at 0.5 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Akirin2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Akirin2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur AKIRIN2

Antigène: AKIRIN2 (Akirin 2 (AKIRIN2))

Autre désignation: Akirin2

Sujet: Akirin2 Antibody: The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-κ,B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-κ,B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-α, and IL-1β, signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

ID gène: 55122

UniProt: Q53H80

Pathways: Positive Regulation of Endopeptidase Activity