OTUD5 Antibody is affinity chromatography purified via peptide column.
Immunogène
OTUD5 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human OTUD5. The immunogen is located within amino acids 400 - 450 of OTUD5.
OTUD5
Reactivité: Humain
WB, IF (cc), IF (p)
Hôte: Lapin
Polyclonal
Alexa Fluor 680
Indications d'application
OTUD5 antibody can be used for detection of OTUD5 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Restrictions
For Research Use only
Format
Liquid
Concentration
1 mg/mL
Buffer
OTUD5 Antibody is supplied in PBS containing 0.02 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C,4 °C
Stockage commentaire
OTUD5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
anticorps DUBA, anticorps AA407879, anticorps AI553596, anticorps BB114028, anticorps DXImx46e, anticorps Sfc7, anticorps otud5, anticorps si:bz30i22.1, anticorps si:rp71-30i22.1, anticorps zgc:154072, anticorps wu:fi28a06, anticorps zgc:100839, anticorps OTU deubiquitinase 5, anticorps OTU domain containing 5, anticorps OTU deubiquitinase 5a, anticorps OTU deubiquitinase 5 S homeolog, anticorps OTU deubiquitinase 5 L homeolog, anticorps OTU deubiquitinase 5b, anticorps OTUD5, anticorps Otud5, anticorps otud5a, anticorps otud5.S, anticorps otud5.L, anticorps otud5b
Sujet
OTUD5 Antibody: OTUD5 is a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and OTUD5 has been shown to suppress the type I interferon (IFN-I)-dependent innate immune response by cleaving the polyubiquitin chain from TRAF3, an essential type I interferon adaptor protein. Cleavage results in disassociation of TRAF3 from a downstream signaling complex containing TBK1 and the disruption of the IFN-I signaling cascade, indicating that OTUD5 acts as a negative regulator of innate immune responses. It has been suggested that by suppressing IFN-I production, OTUD5 may function to inhibit the emergence of certain autoimmune disorders such as systemic lupus erythematosus. Multiple isoforms of OTUD5 are known to exist.