ZNF350 anticorps (C-Term)

N° du produit ABIN6990987

Détail du produit anti-ZNF350 anticorps

Antigène: ZNF350 (Zinc Finger Protein 350 (ZNF350))

Épitope: AA 410-460, C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZNF350 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: ZBRK1 Antibody is affinity chromatography purified via peptide column.

Immunogène: ZBRK1 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of the human ZBRK1. The immunogen is located within amino acids 410 - 460 of ZBRK1.

Isotype: IgG

Information d'application

Indications d'application: ZBRK1 antibody can be used for detection of ZBRK1 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ZBRK1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ZBRK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur ZNF350

Antigène: ZNF350 (Zinc Finger Protein 350 (ZNF350))

Autre désignation: ZBRK1 (ZNF350 Produits)

Synonymes: anticorps ZFQR, anticorps ZBRK1, anticorps zinc finger protein 350, anticorps ZNF350, anticorps znf350

Sujet: ZBRK1 Antibody: ZBRK1 is a member of the Kruppel-associated box-zinc finger protein (KRAB-ZFP) protein family of transcriptional repressors. ZBRK1 has been shown to not only be up-regulated in senescent fibroblasts but also interacts with BRCA1, a transcriptional regulator with tumor suppressor activity. ZBRK1 binds to a specific sequence within the GADD45 gene, supporting the assembly of a nuclear complex containing BRCA1 and repressing its transcription. Recent experiments demonstrate that ZBRK1 can homo-oligomerize in vitro and in vivo through a C-terminal transcriptional repression domain (CTRD), and this oligomerization facilitates the ZBRK1-directed transcriptional repression through ZBRK1 response elements. These results suggest that higher order ZBRK1 oligomers may assemble through both protein-DNA and CTRD-dependent protein-protein interactions.

ID gène: 59348

NCBI Accession: NP_067645

UniProt: Q9GZX5