AAK1 anticorps (C-Term)

N° du produit ABIN6990990

Cet anticorps anti-AAK1 est un anticorps Lapin Polyclonal détectant AAK1 dans WB et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour AAK1 anticorps (C-Term) (ABIN6990990)

Antigène: AAK1 (AP2 associated kinase 1 (AAK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AAK1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-AAK1 anticorps

Épitope: AA 830-880, C-Term

Purification: Aak1 Antibody is affinity chromatography purified via peptide column.

Immunogène: Aak1 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of the human Aak1. The immunogen is located within amino acids 830 - 880 of Aak1.

Isotype: IgG

Information d'application

Indications d'application: Aak1 antibody can be used for detection of Aak1 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Aak1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Aak1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur AAK1

Antigène: AAK1 (AP2 associated kinase 1 (AAK1))

Autre désignation: Aak1

Sujet: Aak1 Antibody: AP2-associated protein kinase 1 (Aak1) is a member of the Ark1/Prk1 subfamily of Ser/Thr protein kinases that are thought to regulate endocytosis by phosphorylating the accessory endocytic components. Aak1 interacts with and phosphorylates the mu2 subunit of the AP-2 complex, which promotes binding of the AP-2 to tyrosine based (Yxxphi) internalization motif-containing receptors and subsequent receptor endocytosis. At least two isoforms of Aak1 are known to exist, the longer isoform contains an extended carboxy-terminus that contains an additional clathrin-binding domain. Overexpression of this long isoform or Aak1 depletion by RNA interference impairs transferrin recycling from the early/sorting endosome, suggesting that Aak1 functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its recycling back to the plasma membrane.

ID gène: 22848

NCBI Accession: NP_055726

UniProt: Q2M2I8