CUEDC2 anticorps (C-Term)

N° du produit ABIN6990994

Cet anticorps Lapin Polyclonal détecte spécifiquement CUEDC2 dans ELISA, WB et ICC. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CUEDC2 anticorps (C-Term) (ABIN6990994)

Antigène: CUEDC2 (CUE Domain Containing 2 (CUEDC2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CUEDC2 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunocytochemistry (ICC)

Détail du produit anti-CUEDC2 anticorps

Épitope: C-Term

Specificité: CUEDC2 antibody will not cross-react with CUEDC1.

Purification: CUEDC2 Antibody is affinity chromatography purified via peptide column.

Immunogène: CUEDC2 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human CUEDC2. The immunogen is located within the last 50 amino acids of CUEDC2.

Isotype: IgG

Information d'application

Indications d'application: CUEDC2 antibody can be used for detection of CUEDC2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: CUEDC2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: CUEDC2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur CUEDC2

Antigène: CUEDC2 (CUE Domain Containing 2 (CUEDC2))

Autre désignation: CUEDC2

Sujet: CUEDC2 Antibody: The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, ~40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC2 (CUE domain-containing protein 2) was found through a yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 also decreases the sumoylation of PR. CUEDC2 has also been found to interact with IKK-alpha and IKK-beta and decrease the activation of NF-κ,B by decreasing the activation of IKK.

Poids moléculaire: Predicted: 32 kDa

Observed: 34 kDa

ID gène: 79004

NCBI Accession: NP_076945

UniProt: Q9H467