AAK1 anticorps (N-Term)
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- Antigène Voir toutes AAK1 Anticorps
- AAK1 (AP2 associated kinase 1 (AAK1))
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Épitope
- AA 190-240, N-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp AAK1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Purification
- Aak1 Antibody is affinity chromatography purified via peptide column.
- Immunogène
- Aak1 antibody was raised against a 20 amino acid synthetic peptide near the amino terminus of the human Aak1. The immunogen is located within amino acids 190 - 240 of Aak1.
- Isotype
- IgG
- Top Product
- Discover our top product AAK1 Anticorps primaire
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- Indications d'application
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Aak1 antibody can be used for detection of Aak1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in mouse samples, Immunocytochemistry in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Aak1 Antibody is supplied in PBS containing 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,4 °C
- Stockage commentaire
- Aak1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Antigène
- AAK1 (AP2 associated kinase 1 (AAK1))
- Autre désignation
- Aak1 (AAK1 Produits)
- Synonymes
- anticorps 5530400K14Rik, anticorps 9630042K20, anticorps AU067724, anticorps AU067726, anticorps BC028270, anticorps C79663, anticorps D6Ertd245e, anticorps R75501, anticorps mKIAA1048, anticorps RGD1563580, anticorps aak1, anticorps si:dkey-261l11.5, anticorps AP2 associated kinase 1, anticorps uncharacterized protein FLJ45252, anticorps AP2 associated kinase 1b, anticorps AAK1, anticorps Aak1, anticorps LOC100512341, anticorps aak1b
- Sujet
- Aak1 Antibody: AP2-associated protein kinase 1 (Aak1) is a member of the Ark1/Prk1 subfamily of Ser/Thr protein kinases that are thought to regulate endocytosis by phosphorylating the accessory endocytic components. Aak1 interacts with and phosphorylates the mu2 subunit of the AP-2 complex, which promotes binding of the AP-2 to tyrosine based (Yxxphi) internalization motif-containing receptors and subsequent receptor endocytosis. At least two isoforms of Aak1 are known to exist, the longer isoform contains an extended carboxy-terminus that contains an additional clathrin-binding domain. Overexpression of this long isoform or Aak1 depletion by RNA interference impairs transferrin recycling from the early/sorting endosome, suggesting that Aak1 functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its recycling back to the plasma membrane.
- ID gène
- 22848
- NCBI Accession
- NP_055726
- UniProt
- Q2M2I8
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