STK39 anticorps (C-Term)

N° du produit ABIN6991000

Cet anticorps Lapin Polyclonal détecte spécifiquement STK39 dans WB, ELISA, IHC (p) et IF. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour STK39 anticorps (C-Term) (ABIN6991000)

Antigène: STK39 (serine threonine Kinase 39 (STK39))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STK39 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-STK39 anticorps

Épitope: AA 450-500, C-Term

Purification: Stk39 Antibody is affinity chromatography purified via peptide column.

Immunogène: Stk39 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human Stk39. The immunogen is located within amino acids 450 - 500 of Stk39.

Isotype: IgG

Information d'application

Indications d'application: Stk39 antibody can be used for detection of stk39 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Stk39 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Stk39 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur STK39

Antigène: STK39 (serine threonine Kinase 39 (STK39))

Autre désignation: Stk39

Sujet: Stk39 Antibody: The serine/threonine kinase Stk39 belongs to the STE20 family, a group of kinases that are known to interact with inflammation-related kinases (such as p38, JNK, NKCC1, PKC-theta, WNK and MLCK), and with transcription factor AP-1. The STE 20 family is involved in diverse biological phenomena, including cell differentiation, cell transformation/ proliferation, cytoskeleton rearrangement, and the regulation of ion transporters. STK39 contains an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain and is abundantly expressed in the brain. STK39 is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled co-transporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. Recent studies show that STK39 tend to be a novel candidate gene for autism and hypertension.

ID gène: 27347

NCBI Accession: NP_037365

UniProt: Q9UEW8