PTCHD2 anticorps (N-Term)

N° du produit ABIN6991021

Cet anticorps Lapin Polyclonal détecte spécifiquement PTCHD2 dans ELISA et IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour PTCHD2 anticorps (N-Term) (ABIN6991021)

Antigène: PTCHD2 (Patched Domain Containing 2 (PTCHD2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTCHD2 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-PTCHD2 anticorps

Épitope: AA 210-260, N-Term

Specificité: At least two isoforms of PTCHD2 are known to exist. This antibody is specific for PTCHD2 and will not recognize the other DISP family of proteins.

Purification: PTCHD2 Antibody is affinity chromatography purified via peptide column.

Immunogène: PTCHD2 antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human PTCHD2. The immunogen is located within amino acids 210 - 260 of PTCHD2.

Isotype: IgG

Information d'application

Indications d'application: PTCHD2 antibody can be used for detection of PTCHD2 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PTCHD2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: PTCHD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur PTCHD2

Antigène: PTCHD2 (Patched Domain Containing 2 (PTCHD2))

Autre désignation: PTCHD2

Sujet: PTCHD2 Antibody: PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.

ID gène: 57540

UniProt: Q9P2K9