Junctophilin 2 anticorps (C-Term)

N° du produit ABIN6991022

L’anticorps Lapin Polyclonal anti-Junctophilin 2 a été validé pour WB, ELISA et IHC (p). Il convient pour détecter Junctophilin 2 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Junctophilin 2 anticorps (C-Term) (ABIN6991022)

Antigène: Junctophilin 2 (JPH2)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Junctophilin 2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Junctophilin 2 anticorps

Épitope: AA 470-520, C-Term

Purification: JPH2 Antibody is affinity chromatography purified via peptide column.

Immunogène: JPH2 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human JPH2. The immunogen is located within amino acids 470 - 520 of JPH2.

Isotype: IgG

Information d'application

Indications d'application: JPH2 antibody can be used for detection of JPH2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: JPH2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: JPH2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur Junctophilin 2

Antigène: Junctophilin 2 (JPH2)

Autre désignation: JPH2

Sujet: JPH2 Antibody: Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain and contribute to the subsurface cistern formation in neurons. JPH2-null mice died of embryonic cardiac arrest and human patients with mutations in the JPH2 gene showed hypertrophic cardiomyopathy, demonstrating the importance of this protein. Multiple isoforms of JPH2 are known to exist.

ID gène: 84502

NCBI Accession: NP_065166

UniProt: Q96JJ6