TTBK2 anticorps (C-Term)

N° du produit ABIN6991063

Cet anticorps Lapin Polyclonal détecte spécifiquement TTBK2 dans ELISA et IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour TTBK2 anticorps (C-Term) (ABIN6991063)

Antigène: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TTBK2 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-TTBK2 anticorps

Épitope: C-Term

Specificité: TTBK2 antibody is human specific. At least four isoforms of TTBK2 are known to exist, this antibody will detect only the two largest isoforms.

Purification: TTBK2 Antibody is affinity chromatography purified via peptide column.

Immunogène: TTBK2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human TTBK2. The immunogen is located within the last 50 amino acids of TTBK2.

Isotype: IgG

Information d'application

Indications d'application: TTBK2 antibody can be used for detection of TTBK2 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TTBK2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: TTBK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TTBK2

Antigène: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Autre désignation: TTBK2

Sujet: TTBK2 Antibody: Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.

ID gène: 146057

UniProt: Q6IQ55