MACC1 anticorps (AA 430-480)

N° du produit ABIN6991128

Cet anticorps anti-MACC1 est un anticorps Lapin Polyclonal détectant MACC1 dans WB, ELISA, IHC (p) et IF. Adapté pour Humain, Rat et Souris.

Aperçu rapide pour MACC1 anticorps (AA 430-480) (ABIN6991128)

Antigène: MACC1 (Metastasis Associated in Colon Cancer 1 (MACC1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MACC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-MACC1 anticorps

Épitope: AA 430-480

Specificité: At least two isoforms of MACC1 are known to exist.

Purification: MACC1 Antibody is affinity chromatography purified via peptide column.

Immunogène: MACC1 antibody was raised against a 17 amino acid synthetic peptide near the center of human MACC1. The immunogen is located within amino acids 430 - 480 of MACC1.

Isotype: IgG

Information d'application

Indications d'application: MACC1 antibody can be used for detection of MACC1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: MACC1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: MACC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur MACC1

Antigène: MACC1 (Metastasis Associated in Colon Cancer 1 (MACC1))

Autre désignation: MACC1

Sujet: MACC1 Antibody: Metastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment.

Poids moléculaire: Predicted: 94 kDa

Observed: 90 kDa

ID gène: 346389

NCBI Accession: NP_877439

UniProt: Q6ZN28