SHoc2/Sur8 anticorps (N-Term)

N° du produit ABIN6991133

Détail du produit anti-SHoc2/Sur8 anticorps

Antigène: SHoc2/Sur8 (SHOC2) (Leucine-rich repeat protein SHOC-2 (SHOC2))

Épitope: AA 30-80, N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SHoc2/Sur8 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: SHOC2 Antibody is affinity chromatography purified via peptide column.

Immunogène: SHOC2 antibody was raised against a 21 amino acid synthetic peptide near the amino terminus of human SHOC2. The immunogen is located within amino acids 30 - 80 of SHOC2.

Isotype: IgG

Information d'application

Indications d'application: SHOC2 antibody can be used for detection of Shoc2 by Western blot at 1-2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: SHOC2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: SHOC2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SHoc2/Sur8

Antigène: SHoc2/Sur8 (SHOC2) (Leucine-rich repeat protein SHOC-2 (SHOC2))

Autre désignation: SHOC2 (SHOC2 Produits)

Synonymes: anticorps AU017287, anticorps Sur8, anticorps mKIAA0862, anticorps SIAA0862, anticorps SOC2, anticorps SUR8, anticorps si:ch211-159c12.3, anticorps si:ch211-197i12.3, anticorps zgc:152956, anticorps soc-2 (suppressor of clear) homolog (C. elegans), anticorps SHOC2 leucine-rich repeat scaffold protein, anticorps SHOC2 leucine-rich repeat scaffold protein S homeolog, anticorps SHOC2, leucine rich repeat scaffold protein, anticorps Shoc2, anticorps shoc2.S, anticorps SHOC2, anticorps shoc2

Sujet: SHOC2 Antibody: SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.

ID gène: 8036

NCBI Accession: NP_031399

UniProt: Q9UQ13