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RWDD3 anticorps (C-Term)

RWDD3 Reactivité: Humain, Souris, Rat WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6991193
  • Antigène Voir toutes RWDD3 Anticorps
    RWDD3 (RWD Domain Containing 3 (RWDD3))
    Épitope
    • 12
    • 8
    • 3
    • 1
    • 1
    C-Term
    Reactivité
    • 22
    • 7
    • 6
    • 2
    • 1
    Humain, Souris, Rat
    Hôte
    • 21
    • 1
    Lapin
    Clonalité
    • 22
    Polyclonal
    Conjugué
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp RWDD3 est non-conjugé
    Application
    • 21
    • 16
    • 15
    • 11
    • 2
    • 2
    Western Blotting (WB), ELISA
    Purification
    RWDD3 Antibody is affinity chromatography purified via peptide column.
    Immunogène
    RWDD3 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human RWDD3. The immunogen is located within the last 50 amino acids of RWDD3.
    Isotype
    IgG
    Top Product
    Discover our top product RWDD3 Anticorps primaire
  • Indications d'application
    RWDD3 antibody can be used for detection of RWDD3 by Western blot at 1 μ,g/mL.

    Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    RWDD3 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    RWDD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    RWDD3 (RWD Domain Containing 3 (RWDD3))
    Autre désignation
    RWDD3 (RWDD3 Produits)
    Synonymes
    anticorps DKFZp469N1913, anticorps RSUME, anticorps 2510027J23Rik, anticorps 3110037C01Rik, anticorps AI035684, anticorps AI662458, anticorps X2CR1, anticorps X2cr1, anticorps zgc:73229, anticorps RWD domain containing 3, anticorps RWDD3, anticorps rwdd3, anticorps Rwdd3
    Sujet
    RWDD3 Antibody: RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases Iκ,Beta sumoylation and stability. In addition, RWDD3 inhibits TNF-α,-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Iκ,Beta increased stability. RSUME-enhanced sumoylation of Iκ,Beta leads to the inhibition of NF-κ,Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.
    ID gène
    25950
    NCBI Accession
    NP_056300
    UniProt
    Q9Y3V2
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