SIPA1L1 anticorps (N-Term)

N° du produit ABIN6991227

Cet anticorps anti-SIPA1L1 Polyclonal Lapin (ABIN6991227) détecte spécifiquement SIPA1L1 dans WB, ELISA, IHC (p) et IF. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SIPA1L1 anticorps (N-Term) (ABIN6991227)

Antigène: SIPA1L1 (Signal-Induced Proliferation-Associated 1 Like 1 (SIPA1L1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIPA1L1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-SIPA1L1 anticorps

Épitope: AA 40-90, N-Term

Purification: SIPA1L1 Antibody is affinity chromatography purified via peptide column.

Immunogène: SIPA1L1 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human SIPA1L1. The immunogen is located within amino acids 40 - 90 of SIPA1L1.

Isotype: IgG

Information d'application

Indications d'application: SIPA1L1 antibody can be used for detection of SIPA1L1 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: SIPA1L1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: SIPA1L1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SIPA1L1

Antigène: SIPA1L1 (Signal-Induced Proliferation-Associated 1 Like 1 (SIPA1L1))

Autre désignation: SIPA1L1

Sujet: SIPA1L1 Antibody: Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.

ID gène: 26037

NCBI Accession: NP_056371

UniProt: O43166