APC1 anticorps (C-Term)

N° du produit ABIN6991321

Cet anticorps Lapin Polyclonal détecte spécifiquement APC1 dans ELISA, WB et IHC (p). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour APC1 anticorps (C-Term) (ABIN6991321)

Antigène: APC1 (ANAPC1) (Anaphase Promoting Complex Subunit 1 (ANAPC1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APC1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-APC1 anticorps

Épitope: AA 1810-1860, C-Term

Purification: APC1 Antibody is affinity chromatography purified via peptide column.

Immunogène: APC1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human APC1. The immunogen is located within amino acids 1810 - 1860 of APC1.

Isotype: IgG

Information d'application

Indications d'application: APC1 antibody can be used for detection of APC1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: APC1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: APC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur APC1

Antigène: APC1 (ANAPC1) (Anaphase Promoting Complex Subunit 1 (ANAPC1))

Autre désignation: APC1

Sujet: APC1 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC1, also known as mitotic checkpoint regulator (MCPR), is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex.

ID gène: 64682

UniProt: Q9H1A4