CDC23 anticorps (AA 270-320)

N° du produit ABIN6991328

L’anticorps Lapin Polyclonal anti-CDC23 a été validé pour WB, ELISA et ICC. Il convient pour détecter CDC23 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CDC23 anticorps (AA 270-320) (ABIN6991328)

Antigène: CDC23 (Cell Division Cycle 23 (CDC23))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDC23 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-CDC23 anticorps

Épitope: AA 270-320

Purification: APC8 Antibody is affinity chromatography purified via peptide column.

Immunogène: APC8 antibody was raised against a 17 amino acid synthetic peptide near the center of human APC8. The immunogen is located within amino acids 270 - 320 of APC8.

Isotype: IgG

Information d'application

Indications d'application: APC8 antibody can be used for detection of APC8 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: APC8 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: APC8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur CDC23

Antigène: CDC23 (Cell Division Cycle 23 (CDC23))

Autre désignation: APC8

Sujet: APC8 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC8 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. In Drosophila, silencing of APC8 results in developmental delay and pupal lethality with elevated levels of apoptosis, high mitotic index, and delayed or blocked mitosis.

ID gène: 8697

UniProt: Q9UJX2

Pathways: Protein targeting to Nucleus