SCUBE3 anticorps (AA 440-490)

N° du produit ABIN6991375

Cet anticorps Lapin Polyclonal détecte spécifiquement SCUBE3 dans ELISA et IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour SCUBE3 anticorps (AA 440-490) (ABIN6991375)

Antigène: SCUBE3 (Signal Peptide, CUB Domain, EGF-Like 3 (SCUBE3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SCUBE3 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-SCUBE3 anticorps

Épitope: AA 440-490

Purification: SCUBE3 Antibody is affinity chromatography purified via peptide column.

Immunogène: SCUBE3 antibody was raised against a 15 amino acid peptide near the center of human SCUBE3. The immunogen is located within amino acids 440 - 490 of SCUBE3.

Isotype: IgG

Information d'application

Indications d'application: SCUBE3 antibody can be used for detection of SCUBE3 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: SCUBE3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: SCUBE3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur SCUBE3

Antigène: SCUBE3 (Signal Peptide, CUB Domain, EGF-Like 3 (SCUBE3))

Autre désignation: SCUBE3

Sujet: SCUBE3 Antibody: SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart (1,2). Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting that it may also play a role in the regulation of cardiac growth. SCUBE3 has been shown to be an endogenous TGF-beta receptor ligand (3,4) and is thought to promote lung cancer cell mobility and invasiveness. In lung cancer cells, the secreted SCUBE3 protein was cleaved by MMP2 and MMP9, allowing the activation of the TGF-beta receptor, the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-beta1, VEGF, Snail, and Slug.

Poids moléculaire: Predicted: 109 kDa

ID gène: 222663

NCBI Accession: NP_689966

UniProt: Q8IX30