PIWIL2 anticorps (AA 460-510)

N° du produit ABIN6991435

Cet anticorps Lapin Polyclonal détecte spécifiquement PIWIL2 dans ELISA et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PIWIL2 anticorps (AA 460-510) (ABIN6991435)

Antigène: PIWIL2 (Piwi-Like 2 (PIWIL2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIWIL2 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-PIWIL2 anticorps

Épitope: AA 460-510

Purification: PIWI-L2 Antibody is affinity chromatography purified via peptide column.

Immunogène: PIWI-L2 antibody was raised against a 14 amino acid synthetic peptide near the center of human PIWI-L2. The immunogen is located within amino acids 460 - 510 of PIWI-L2.

Isotype: IgG

Information d'application

Indications d'application: PIWI-L2 antibody can be used for detection of PIWI-L2 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PIWI-L2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: PIWI-L2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur PIWIL2

Antigène: PIWIL2 (Piwi-Like 2 (PIWIL2))

Autre désignation: PIWI-L2

Sujet: PIWI-L2 Antibody: PIWI-L2 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L2 has been implicated in multiple roles including stem cell self-renewal and is highly expressed in many breast cancers. In these tumors, PIWI-L2 silences the expression of STAT3, a regulator of Bcl-XL and cyclin D1, allowing the proliferation and survival of breast cancer stem cells. Recent studies have shown that overexpression of PIWI-like proteins are potential biomarkers for colon and other cancers.

ID gène: 55124

NCBI Accession: NP_00129193

UniProt: Q8TC59

Pathways: Stem Cell Maintenance