SIK2 anticorps (AA 270-320)

N° du produit ABIN6991528

Cet anticorps Lapin Polyclonal détecte spécifiquement SIK2 dans WB, ELISA, IF et ICC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour SIK2 anticorps (AA 270-320) (ABIN6991528)

Antigène: SIK2 (Salt-Inducible Kinase 2 (SIK2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIK2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-SIK2 anticorps

Épitope: AA 270-320

Specificité: SIK2 antibody is predicted to not cross-react with other SIK protein family members.

Purification: SIK2 Antibody is affinity chromatography purified via peptide column.

Immunogène: SIK2 antibody was raised against a 16 amino acid synthetic peptide near the center of human SIK2. The immunogen is located within amino acids 270 - 320 of SIK2.

Isotype: IgG

Information d'application

Indications d'application: SIK2 antibody can be used for detection of SIK2 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: SIK2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: SIK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SIK2

Antigène: SIK2 (Salt-Inducible Kinase 2 (SIK2))

Autre désignation: SIK2

Sujet: SIK2 Antibody: Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1 alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.

ID gène: 23235

UniProt: Q9H0K1