SEC62 antibody is predicted to not cross-react with other SEC proteins. Multiple isoforms of SEC62 are known to exist.
Purification
SEC62 Antibody is affinity chromatography purified via peptide column.
Immunogène
SEC62 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SEC62. The immunogen is located within amino acids 270 - 320 of SEC62.
TLOC1
Reactivité: Humain, Souris, Rat
IF (cc), IF (p)
Hôte: Lapin
Polyclonal
Alexa Fluor 680
Indications d'application
SEC62 antibody can be used for detection of SEC62 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in rat samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Restrictions
For Research Use only
Format
Liquid
Concentration
1 mg/mL
Buffer
SEC62 Antibody is supplied in PBS containing 0.02 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C,4 °C
Stockage commentaire
SEC62 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
anticorps tloc1, anticorps TLOC1, anticorps wu:fb57b06, anticorps zgc:114073, anticorps Dtrp1, anticorps HTP1, anticorps TP-1, anticorps 3100002M17Rik, anticorps AI844545, anticorps AW545092, anticorps Tloc1, anticorps Ab2-292, anticorps SEC62 homolog, preprotein translocation factor S homeolog, anticorps SEC62 homolog, preprotein translocation factor, anticorps membrane unit of ER protein translocation apparatus, anticorps SEC62 homolog (S. cerevisiae), anticorps sec62.S, anticorps SEC62, anticorps sec62, anticorps Sec62
Sujet
SEC62 Antibody: SEC62 is an integral membrane protein located in the rough endoplasmic reticulum (ER) and is part of the SEC61-SEC62-SEC63 complex that is the central component of the protein translocation apparatus of the ER membrane. It is speculated that SEC61-SEC62-SEC63 may perform post-translational protein translocation into the ER and might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Silencing of this gene with RNAi dramatically reduced the migration and invasive potential of numerous tumor cell lines, suggesting that it may be an attractive target for therapy of various tumors.