EI24 anticorps (C-Term)

N° du produit ABIN6991581

Cet anticorps anti-EI24 est un anticorps Lapin Polyclonal détectant EI24 dans WB, ELISA et IHC (p). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour EI24 anticorps (C-Term) (ABIN6991581)

Antigène: EI24 (Etoposide Induced 2.4 (EI24))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EI24 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-EI24 anticorps

Épitope: C-Term

Specificité: At least two isoforms of EI24 are known to exist, this antibody will only detect the larger isoform.

Purification: EI24 Antibody is affinity chromatography purified via peptide column.

Immunogène: EI24 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human EI24. The immunogen is located within the last 50 amino acids of EI24.

Isotype: IgG

Information d'application

Indications d'application: EI24 antibody can be used for detection of EI24 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: EI24 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: EI24 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur EI24

Antigène: EI24 (Etoposide Induced 2.4 (EI24))

Autre désignation: EI24

Sujet: EI24 Antibody: The etoposide-induced 24 (EI24) protein is an immediate-early induction target of p53-mediated apoptosis and functions as a tumor suppressor. EI24 contains six transmembrane domains and is localized to the endoplasmic reticulum (ER). It binds to Bcl-2 and may contribute to apoptosis by modulating the activity and function of Bcl-2. EI24 is highly mutated in aggressive breast cancers and its loss in breast cancer tissue correlates with tumor invasiveness. Similar findings in invasive cervical carcinoma suggest that EI24 may be a promising therapeutic target in the treatment of invasive cancer.

ID gène: 9538

NCBI Accession: NP_004870

UniProt: O14681