AFAP anticorps (N-Term)

N° du produit ABIN6991604

L’anticorps Lapin Polyclonal anti-AFAP a été validé pour WB et ELISA. Il convient pour détecter AFAP dans des échantillons de Humain et Souris.

Aperçu rapide pour AFAP anticorps (N-Term) (ABIN6991604)

Antigène: AFAP (AFAP1) (Actin Filament Associated Protein 1 (AFAP1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AFAP est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-AFAP anticorps

Épitope: AA 30-80, N-Term

Specificité: Monomer and homomultimer of AFAP1 are known to exist, AFAP1 antibody is predicted to not cross-react with other AFAP family members.

Purification: AFAP1 Antibody is affinity chromatography purified via peptide column.

Immunogène: AFAP1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human AFAP1. The immunogen is located within amino acids 30 - 80 of AFAP1.

Isotype: IgG

Information d'application

Indications d'application: AFAP1 antibody can be used for detection of AFAP1 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: AFAP1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: AFAP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur AFAP

Antigène: AFAP (AFAP1) (Actin Filament Associated Protein 1 (AFAP1))

Autre désignation: AFAP1

Sujet: AFAP1 Antibody: The actin filament-associated protein AFAP1 (AFAP-110) is an actin cross-linking protein first identified as a substrate of the viral oncogene v-Src. AFAP1 has a fundamental role in actin cytoskeleton arrangement. It contains a carboxyterminal actin-binding domain that directly binds to F-actin and serves as an adaptor protein in the regulation of SRC and PKC signal transduction by several functional domains, including 2 pleckstrin homology (PH) domains, a Src homology 3-binding (SH3-binding) motif, and several SH2-binding motifs. It is overexpressed in prostate carcinoma and contributes to tumor growth by regulating cell-matrix adhesions and migration in the cancer cells. AFAP1 represent a possible therapeutic target for controlling tumorigenesis and metastasis.

ID gène: 60312

NCBI Accession: NP_940997

UniProt: Q8N556