TRIM21 anticorps (AA 290-340)

N° du produit ABIN6991636

Détail du produit anti-TRIM21 anticorps

Antigène: TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Épitope: AA 290-340

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM21 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: TRIM21 antibody is human specific. This antibody is predicted to not cross-react with TRIM6.

Purification: TRIM21 antibody is affinity chromatography purified via peptide column.

Immunogène: Anti-TRIM21 antibody was raised against a peptide corresponding to 16 amino acids near the center of human TRIM21. The immunogen is located within amino acids 290-340 of TRIM21.

Isotype: IgG

Information d'application

Indications d'application: WB: 0.5-2 μ,g/mL, IHC: 5 μ,g/mL, IF: 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TRIM21 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: TRIM21 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Détails sur TRIM21

Antigène: TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Autre désignation: TRIM21 (TRIM21 Produits)

Synonymes: anticorps RNF81, anticorps RO52, anticorps SSA, anticorps SSA1, anticorps Ro52, anticorps Ssa1, anticorps tripartite motif containing 21, anticorps tripartite motif-containing 21, anticorps TRIM21, anticorps Trim21

Sujet: TRIM21, a member of the tripartite motif (TRIM) family, is a part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus (1). RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus (2). TRIM21 also acts as a cytosolic antibody receptor, detection of intracellular antibodies activate immune signaling by stimulating the transcription factor pathways of NF-kappaB, AP-1, IRF3, IRF5, and IRF7, resulting in the production of proinflammatory cytokines and the induction of an antiviral state (3).

Poids moléculaire: Predicted: 54kD

Observed: 54 kD kDa

ID gène: 6737

NCBI Accession: NP_003132

UniProt: P19474