CP110 anticorps (C-Term)

N° du produit ABIN6991685

Détail du produit anti-CP110 anticorps

Antigène: CP110 (CCP110) (Centriolar Coiled Coil Protein 110kDa (CCP110))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CP110 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificité: Two isoforms of CCP110 are known to exist, this antibody will only detect the longer isoform

Purification: CCP110 Antibody is affinity chromatography purified via peptide column.

Immunogène: CCP110 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human CCP110. The immunogen is located within the last 50 amino acids of CCP110.

Isotype: IgG

Information d'application

Indications d'application: CCP110 antibody can be used for detection of CCP110 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: CCP110 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: CCP110 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur CP110

Antigène: CP110 (CCP110) (Centriolar Coiled Coil Protein 110kDa (CCP110))

Autre désignation: CCP110 (CCP110 Produits)

Synonymes: anticorps 6330503K22Rik, anticorps AA415922, anticorps AI427129, anticorps AW557948, anticorps CP110, anticorps Cep110, anticorps Cp110, anticorps RGD1310509, anticorps centriolar coiled coil protein 110, anticorps centriolar coiled-coil protein 110, anticorps Ccp110, anticorps CCP110

Sujet: CCP110 Antibody: CCP110 is a centrosomal protein required for the centrosome to function as a microtubule organizing center and plays an essential role in centrosome duplication. It is a target of cyclin-dependent kinases (CDKs), disruption of CCP110 phosphorylation leads to unscheduled centrosome separation and polyploidy. CCP110 is also a target of SCF (Cyclin F) ubiquitin ligase complex, leading to its degradation, suggesting that this complex controls centrosome homeostasis and mitotic fidelity through CCP110 degradation. The centriolar kinesin Kif24 also interacts with CP110 and remodel microtubules and regulate ciliogenesis.

Poids moléculaire: Predicted: 110 kDa

Observed: 110 kDa

ID gène: 9738

NCBI Accession: NP_001185951

UniProt: O43303

Pathways: M Phase