TOX anticorps (N-Term)

N° du produit ABIN6991735

Cet anticorps Lapin Polyclonal détecte spécifiquement TOX dans WB, ELISA et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour TOX anticorps (N-Term) (ABIN6991735)

Antigène: TOX (Thymus High Mobility Group Box Protein (TOX))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TOX est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-TOX anticorps

Épitope: AA 130-180, N-Term

Specificité: No alternatively spliced transcript variants have been observed.

Purification: TOX Antibody is affinity chromatography purified via peptide column.

Immunogène: TOX antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human TOX. The immunogen is located within amino acids 130 - 180 of TOX.

Isotype: IgG

Information d'application

Indications d'application: TOX antibody can be used for detection of TOX by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: TOX Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: TOX antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur TOX

Antigène: TOX (Thymus High Mobility Group Box Protein (TOX))

Autre désignation: TOX

Sujet: TOX Antibody: TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development. It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells.

Poids moléculaire: 58 kDa

ID gène: 9760

NCBI Accession: NP_055544

UniProt: O94900