ATG2B anticorps (N-Term)

N° du produit ABIN6991740

Cet anticorps anti-ATG2B est un anticorps Lapin Polyclonal détectant ATG2B dans WB, ELISA et IF. Adapté pour Humain.

Aperçu rapide pour ATG2B anticorps (N-Term) (ABIN6991740)

Antigène: ATG2B (Autophagy Related 2B (ATG2B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG2B est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-ATG2B anticorps

Épitope: AA 450-500, N-Term

Specificité: ATG2B antibody is predicted to not cross-react with other ATG2A.

Purification: ATG2B Antibody is affinity chromatography purified via peptide column.

Immunogène: ATG2B antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human ATG2B. The immunogen is located within amino acids 450 - 500 of ATG2B.

Isotype: IgG

Information d'application

Indications d'application: ATG2B antibody can be used for detection of ATG2B by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ATG2B Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ATG2B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur ATG2B

Antigène: ATG2B (Autophagy Related 2B (ATG2B))

Autre désignation: ATG2B

Sujet: ATG2B Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is ATG2B, one of two homologs of ATG2 that is essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. Relatively high rates of ATG2B mutations were observed in gastric and colorectal carcinomas, suggesting that deregulating the autophagy process may contribute to cancer development.

Poids moléculaire: 229 kDa

ID gène: 55102

NCBI Accession: NP_060506

UniProt: Q96BY7