PHLPP2 anticorps (C-Term)

N° du produit ABIN6991747

Cet anticorps Lapin Polyclonal détecte spécifiquement PHLPP2 dans WB, ELISA, IF et ICC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PHLPP2 anticorps (C-Term) (ABIN6991747)

Antigène: PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PHLPP2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-PHLPP2 anticorps

Épitope: C-Term

Specificité: At least three isoforms are known to exist, this antibody will detect the two largest isoforms. PHLPP2 antibody is predicted to not cross react with PHLPP1.

Purification: PHLPP2 Antibody is affinity chromatography purified via peptide column.

Immunogène: PHLPP2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human PHLPP2. The immunogen is located within the last 50 amino acids of PHLPP2.

Isotype: IgG

Information d'application

Indications d'application: PHLPP2 antibody can be used for detection of PHLPP2 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PHLPP2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: PHLPP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur PHLPP2

Antigène: PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))

Autre désignation: PHLPP2

Sujet: PHLPP2 Antibody: PHLPP2 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. PHLPP2 associates with and is inhibited by adenylyl cyclase type 6 (AC6), thereby allowing Akt activation.

Poids moléculaire: 156 kDa

ID gène: 23035

NCBI Accession: NP_055835

UniProt: Q6ZVD8

Pathways: Signalisation PI3K-Akt, Fc-epsilon Receptor Signaling Pathway