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PHLPP2 anticorps (C-Term)

PHLPP2 Reactivité: Humain WB, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6991747
  • Antigène Voir toutes PHLPP2 Anticorps
    PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
    Épitope
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 16
    • 5
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 15
    • 1
    Lapin
    Clonalité
    • 16
    Polyclonal
    Conjugué
    • 16
    Cet anticorp PHLPP2 est non-conjugé
    Application
    • 15
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    At least three isoforms are known to exist, this antibody will detect the two largest isoforms. PHLPP2 antibody is predicted to not cross react with PHLPP1.
    Purification
    PHLPP2 Antibody is affinity chromatography purified via peptide column.
    Immunogène
    PHLPP2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human PHLPP2. The immunogen is located within the last 50 amino acids of PHLPP2.
    Isotype
    IgG
    Top Product
    Discover our top product PHLPP2 Anticorps primaire
  • Indications d'application
    PHLPP2 antibody can be used for detection of PHLPP2 by Western blot at 1 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PHLPP2 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,4 °C
    Stockage commentaire
    PHLPP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Antigène
    PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
    Autre désignation
    PHLPP2 (PHLPP2 Produits)
    Synonymes
    anticorps PHLPPL, anticorps phlppl, anticorps AI481772, anticorps C130044A18Rik, anticorps Phlppl, anticorps RGD1562857, anticorps PH domain and leucine rich repeat protein phosphatase 2, anticorps PH domain and leucine rich repeat protein phosphatase 2 S homeolog, anticorps PHLPP2, anticorps phlpp2.S, anticorps phlpp2, anticorps Phlpp2
    Sujet
    PHLPP2 Antibody: PHLPP2 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. PHLPP2 associates with and is inhibited by adenylyl cyclase type 6 (AC6), thereby allowing Akt activation.
    Poids moléculaire
    156 kDa
    ID gène
    23035
    NCBI Accession
    NP_055835
    UniProt
    Q6ZVD8
    Pathways
    Signalisation PI3K-Akt, Fc-epsilon Receptor Signaling Pathway
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