Pellino 1 anticorps (C-Term)

N° du produit ABIN6991769

L’anticorps Lapin Polyclonal anti-Pellino 1 a été validé pour WB, ELISA, ICC et IF. Il convient pour détecter Pellino 1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Pellino 1 anticorps (C-Term) (ABIN6991769)

Antigène: Pellino 1 (PELI1) (Pellino E3 Ubiquitin Protein Ligase 1 (PELI1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Pellino 1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-Pellino 1 anticorps

Épitope: AA 300-350, C-Term

Purification: Pellino 1 Antibody is affinity chromatography purified via peptide column.

Immunogène: Rabbit polyclonal Pellino 1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human Pellino 1. The immunogen is located within amino acids 300 - 350 of Pellino 1.

Isotype: IgG

Information d'application

Indications d'application: Pellino 1 antibody can be used for detection of Pellino 1 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Pellino 1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: Pellino 1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur Pellino 1

Antigène: Pellino 1 (PELI1) (Pellino E3 Ubiquitin Protein Ligase 1 (PELI1))

Autre désignation: Pellino 1

Sujet: Pellino 1 Antibody: The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-κ,B. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-ε, and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation.

Poids moléculaire: 46 kDa

ID gène: 57162

NCBI Accession: NP_065702

UniProt: Q96FA3

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades